Corneal transplantation constitutes one of the leading treatments for
severe cases of loss of corneal function. Due to its limitations, a
concerted effort has been made by tissue engineers to produce
functional, synthetic corneal prostheses as an alternative recourse.
However, successful translation of these therapies into the clinic has
not yet been accomplished. 3D bioprinting is an emerging technology that
can be harnessed for the fabrication of biological tissue for clinical
applications. We applied this to the area of corneal tissue engineering
in order to fabricate corneal structures that resembled the structure of
the native human corneal stroma using an existing 3D digital human
corneal model and a suitable support structure. These were 3D bioprinted
from an in-house collagen-based bio-ink containing encapsulated corneal
keratocytes. Keratocytes exhibited high cell viability both at day 1
post-printing (>90%) and at day 7 (83%). We established 3D
bio-printing to be a feasible method by which artificial corneal
structures can be engineered.
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